INT progressing with the development of PDX models

INT progressing

PDX models involve mice into which human EHE tumour tissue is implanted to keep it alive and allow it to grow. If successful, samples of the tumour tissue from the first mouse are then transferred to additional mice to accommodate further growth. Tissue samples may then also be used to create EHE cells lines where the EHE cells are grown in petri dishes, providing another type of EHE model that is critical for research – an EHE cell line. Disease models like cell lines and PDX can then be used in ongoing biomarker and drug screening studies. 

To date, INT have generated one PDX model which has been validated and reproduces all the key characteristics of the original human EHE tumour. The PDX is currently being used to assess the activity of drugs.    

Andrei Ivanescu, President of EHE Italia,  who was attending the first such research overview was excited: 

It was amazing for me to see and hear all that the team at INT are doing to help us find ways to better treat this disease. There is so much going on, and so many positive results being reported. I was also delighted to see the level of collaboration that is already taking place between the EHE Group advocates and the researchers and clinicians in Italy, the UK and Canada. I am convinced that with this high level of international collaboration between all the EHE stake-holders we are already making significant progress in understanding this disease and will bring forward the day when we can genuinely manage and treat the disease.